RT Journal Article
SR Electronic
T1 GRAND: A database of gene regulatory network models across human conditions
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.06.18.448997
DO 10.1101/2021.06.18.448997
A1 Marouen Ben Guebila
A1 Camila M Lopes-Ramos
A1 Deborah Weighill
A1 Abhijeet Rajendra Sonawane
A1 Rebekka Burkholz
A1 Behrouz Shamsaei
A1 John Platig
A1 Kimberly Glass
A1 Marieke L Kuijjer
A1 John Quackenbush
YR 2021
UL http://biorxiv.org/content/early/2021/06/18/2021.06.18.448997.abstract
AB Gene regulation plays a fundamental role in shaping tissue identity, function, and response to perturbation. Regulatory processes are controlled by complex networks of interacting elements, including transcription factors, miRNAs and their target genes. The structure of these networks helps to determine phenotypes and can ultimately influence the development of disease or response to therapy. We developed GRAND (https://grand.networkmedicine.org) as a database for gene regulatory network models that can be compared between biological states, or used to predict which drugs produce changes in regulatory network structure. The database includes 12,468 genome-scale networks covering 36 human tissues, 28 cancers, 1,378 unperturbed cell lines, as well as 173,013 TF and gene targeting scores for 2,858 small molecule-induced cell line perturbation paired with phenotypic information. GRAND allows the networks to be queried using phenotypic information and visualized using a variety of interactive tools. In addition, it includes a web application that matches disease states to potentially therapeutic small molecule drugs using regulatory network properties.Modeling gene regulation across human conditions integrates cancer tissues and cell lines, small molecules, and normal tissue networks.Competing Interest StatementThe authors have declared no competing interest.