TY - JOUR T1 - Flying in the Face of Adversity: A Drosophila-based Virtual CURE Provides Semester-long Authentic Research Opportunity to the Flipped Classroom JF - bioRxiv DO - 10.1101/2021.06.28.450232 SP - 2021.06.28.450232 AU - Edward A. Waddell AU - Dara Ruiz-Whalen AU - Alana M. O’Reilly AU - Nathan T. Fried Y1 - 2021/01/01 UR - http://biorxiv.org/content/early/2021/06/30/2021.06.28.450232.abstract N2 - A call for the integration of research experiences into all biology curricula has been a major goal for educational reform efforts nationally. Course-Based Undergraduate Research Experiences (CUREs) have been the predominant method of accomplishing this, but their associated costs and complex design can limit their wide adoption. In 2020, the COVID-19 pandemic forced programs to identify unique ways to still provide authentic research experiences while students were virtual. We report here a full guide for the successful implementation of a semester-long virtual CURE that uses Drosophila behavioral assays to explore the connection between pain and addiction with the use of a “lab-in-a-box” sent home to students. Individual components were piloted across three semesters and launched as a 100-level introductory course with 19 students. We found that this course increased science identity and successfully improved key research competencies as per the Undergraduate Research Student Self-Assessment (URSSA) survey. This course is ideal for flipped classrooms ranging from introductory biology to upper-level neuroscience courses and can be integrated directly into the lecture period without the need for building a new course. Given the low cost, recent comfort with virtual learning environments, and the current proliferation of flipped biology classrooms following the 2020 pandemic, this curriculum could serve as an ideal project-based active-learning tool for equitably increasing access to authentic research experiences.Competing Interest StatementThe corresponding author, Nathan T. Fried, and Edward A. Waddell declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Dara Ruiz-Whalen and Alana M. O'Reilly declare that they are the Chief Learning and Chief Scientific Officers, respectively, for the Philadelphia-based non-profit organization, eCLOSE Institute. ER -