RT Journal Article
SR Electronic
T1 A model of rapid homeostatic plasticity accounts for hidden, long-lasting changes in a neuronal circuit after exposure to high potassium
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.07.01.450770
DO 10.1101/2021.07.01.450770
A1 Mara C.P. Rue
A1 Leandro Alonso
A1 Eve Marder
YR 2021
UL http://biorxiv.org/content/early/2021/07/01/2021.07.01.450770.abstract
AB Neural circuits must both function reliably and flexibly adapt to changes in their environment. We studied how both biological neurons and computational models respond to high potassium concentrations. Pyloric neurons of the crab stomatogastric ganglion (STG) initially become quiescent, then recover spiking activity in high potassium saline. The neurons retain this adaptation and recover more rapidly in subsequent high potassium applications, even after hours in control saline. We constructed a novel activity-dependent computational model that qualitatively captures these results. In this model, regulation of conductances is gated on and off depending on how far the neuron is from its target activity. This allows the model neuron to retain a trace of past perturbations even after it returns to its target activity in control conditions. Thus, perturbation, followed by recovery of normal activity, can hide cryptic changes in neuronal properties that are only revealed by subsequent perturbations.Competing Interest StatementThe authors have declared no competing interest.