PT  - JOURNAL ARTICLE
AU  - Pasqualina Guida
AU  - Mario Michiels
AU  - Peter Redgrave
AU  - David Luque
AU  - Ignacio Obeso
TI  - Striatal role in everyday-life and laboratory-developed habits
AID  - 10.1101/2021.07.02.450904
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.07.02.450904
4099  - http://biorxiv.org/content/early/2021/07/04/2021.07.02.450904.short
4100  - http://biorxiv.org/content/early/2021/07/04/2021.07.02.450904.full
AB  - The dorsolateral striatum plays a major role in stimulus-response habits that are learned in the experimental laboratory. Here, we use meta-analytic procedures to identify the neural circuits activated during the execution of stimulus-response behaviours acquired in everyday-life and those activated by habits acquired in the laboratory. In the case of everyday-life habits we dissociated motor and associative components. We found that motor-dominant stimulus-response associations developed outside the laboratory engaged posterior dorsal putamen, supplementary motor area (SMA) and cerebellum. Associative components were also represented in the posterior putamen. Meanwhile, newly learned habits relied more on the anterior putamen with activation expanding to caudate and nucleus accumbens. Importantly, common neural representations for both naturalistic and laboratory based habits were found in posterior left and anterior right putamen. Our findings suggest a common striatal substrate for behaviours with significant stimulus-response associations, independently of whether they were acquired in the laboratory or everyday-life.Competing Interest StatementThe authors have declared no competing interest.