RT Journal Article
SR Electronic
T1 Time-resolved structure-function coupling in brain networks
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.07.08.451672
DO 10.1101/2021.07.08.451672
A1 Zhen-Qi Liu
A1 Bertha Vázquez-Rodríguez
A1 R. Nathan Spreng
A1 Boris C. Bernhardt
A1 Richard F. Betzel
A1 Bratislav Misic
YR 2021
UL http://biorxiv.org/content/early/2021/07/09/2021.07.08.451672.abstract
AB The relationship between structural and functional connectivity in the brain is a key question in systems neuroscience. Modern accounts assume a single global structure-function relationship that persists over time. Here we show that structure-function coupling is dynamic and regionally heterogeneous. We use a temporal unwrapping procedure to identify moment-to-moment co-fluctuations in neural activity, and reconstruct time-resolved structure-function coupling patterns. We find that patterns of dynamic structure-function coupling are highly organized across the cortex. These patterns reflect cortical hierarchies, with stable coupling in unimodal and transmodal cortex, and dynamic coupling in intermediate regions, particularly in insular cortex (salience network) and frontal eye fields (dorsal attention network). Finally, we show that the variability of structure-function coupling is shaped by the distribution of connection lengths. The time-varying coupling of structural and functional connectivity points towards an informative feature of the brain that may reflect how cognitive functions are flexibly deployed and implemented.Competing Interest StatementThe authors have declared no competing interest.