TY - JOUR T1 - A Structure-based B-cell Epitope Prediction Model Through Combing Local and Global Features JF - bioRxiv DO - 10.1101/2021.07.13.452188 SP - 2021.07.13.452188 AU - Shuai Lu AU - Yuguang Li AU - Xiaofei Nan AU - Shoutao Zhang Y1 - 2021/01/01 UR - http://biorxiv.org/content/early/2021/07/14/2021.07.13.452188.abstract N2 - B-cell epitopes (BCEs) are a set of specific sites on the surface of an antigen that binds to an antibody produced by B-cell. The recognition of epitopes is a major challenge for drug design and vaccines development. Compared with experimental methods, computational approaches have strong potential for epitope prediction at much lower cost. Moreover, most of the currently methods focus on using local information around target amino acid residue for BCEs prediction without taking the global information of the whole antigen sequence into consideration.We propose a novel deep leaning method thorough combing local features and global features for BCEs prediction. In our model, two parallel modules are built to extract local and global features from the antigen separately. For local features, we use graph convolutional networks to capture information of spatial neighbors of a target amino acid residue. For global features, Attention based Bidirectional Long Short-Term Memory networks (Att-BLTM) are applied to extract information from the whole antigen sequence. Then the local and global features are combined to predict BCEs. The experiments show that the proposed method achieves superior performance over the state-of-the-art BCEs prediction methods on benchmark datasets. Also, we compare the performance differences between data with or without global features. The experimental results show that global features play an important role in BCEs prediction.Competing Interest StatementThe authors have declared no competing interest. ER -