RT Journal Article
SR Electronic
T1 Obsessive Compulsive Disorder and Response Inhibition: Meta-analysis of the Stop-Signal Task
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.07.16.452538
DO 10.1101/2021.07.16.452538
A1 Kendall Mar
A1 Parker Townes
A1 Petros Pechlivanoglou
A1 Paul Arnold
A1 Russell Schachar
YR 2021
UL http://biorxiv.org/content/early/2021/07/16/2021.07.16.452538.abstract
AB This systematic review and meta-analysis updates evidence pertaining to deficient response inhibition in obsessive-compulsive disorder (OCD) as measured by the stop-signal task (SST). We conducted a meta-analysis of the literature to compare response inhibition in patients with OCD and healthy controls, meta-regressions to determine relative influences of age and sex on response inhibition impairment, and a risk of bias assessment for included studies using the Newcastle-Ottawa Scale (NOS). Stop-signal reaction time (SSRT), which estimates the latency of the stopping process deficit, was significantly longer in OCD samples than in controls, reflecting inferior inhibitory control (Raw mean difference = 23.43ms; p = <0.001; 95% CI = [17.42, 29.45]). We did not observe differences in mean reaction time (MRT) in OCD compared to controls (Raw mean difference = 2.51ms; p = 0.755; 95% CI = [−13.27, 18.30]). Age impacted effect size of SSRT, indicating a greater deficit in older patients than younger ones. We did not observe a significant effect of sex on SSRT or MRT scores.General Scientific Summary Difficulty inhibiting responses is an hypothesized deficit in Obsessive-Compulsive Disorder (OCD). The results of this systematic review and meta-analysis of studies using the Stop Signal Task support the notion of deficient response inhibition in OCD and indicate that older individuals with OCD show greater impairments than younger ones.Competing Interest StatementThe authors have declared no competing interest.