PT  - JOURNAL ARTICLE
AU  - Guo Li
AU  - Liwen Wang
AU  - Chaoyu Ma
AU  - Wei Liao
AU  - Yong Liu
AU  - Shruti Mishra
AU  - Xin Zhang
AU  - Yuanzheng Qiu
AU  - Qianjin Lu
AU  - Nu Zhang
TI  - TGF-β-dependent Lymphoid Tissue Residency of Stem-like T cells Limits the Response to Tumor Vaccine
AID  - 10.1101/2021.07.19.452945
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.07.19.452945
4099  - http://biorxiv.org/content/early/2021/07/19/2021.07.19.452945.short
4100  - http://biorxiv.org/content/early/2021/07/19/2021.07.19.452945.full
AB  - Stem-like CD8+ T cells represent the key subset responding to multiple tumor immunotherapies, including tumor vaccination. However, the signals that control the differentiation of stem-like T cells are not entirely known. Most previous investigations on stem-like T cells are focused on tumor infiltrating T cells (TIL). The behavior of stem-like T cells in other tissues remains to be elucidated. Tissue-resident memory T cells (TRM) are often defined as a non-circulating T cell population residing in non-lymphoid tissues. TILs carrying TRM features are associated with better tumor control. Here, we found that stem-like CD8+ T cells differentiated into TRMs in a TGF-β and tumor antigen dependent manner almost exclusively in tumor draining lymph node (TDLN). TDLN-resident stemlike T cells were negatively associated with the response to tumor vaccine. In other words, after tumor vaccine, TDLN stem-like T cells transiently lost TRM features, differentiated into migratory effectors and exerted tumor control.Competing Interest StatementThe authors have declared no competing interest.