RT Journal Article
SR Electronic
T1 Developmental stage-specific patterned activity contributes to callosal axon projections
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.07.21.453297
DO 10.1101/2021.07.21.453297
A1 Yuta Tezuka
A1 Kenta M. Hagihara
A1 Kenichi Ohki
A1 Tomoo Hirano
A1 Yoshiaki Tagawa
YR 2021
UL http://biorxiv.org/content/early/2021/07/22/2021.07.21.453297.abstract
AB The developing neocortex exhibits patterned spontaneous network activity with various synchrony levels. However, the role of such activity in the formation of cortical circuits remains unclear. We previously reported that the development of callosal axon projections, one of the major long-range axonal projections in the brain, is activity dependent. Here, using a genetic method to manipulate network activity in a stage-specific manner, we demonstrated that spontaneous cortical network activity contributes to the region- and lamina-specific projections of callosal axons in the mouse visual cortex and that this process has a “critical period”: restoring neuronal activity during that period resumed the projections, whereas restoration after the period failed. Furthermore, in vivo imaging revealed that less correlated network activity was critical. Together, our findings suggest that a distinct pattern of spontaneous network activity in a specific developmental stage underlies the formation of long-range axonal projections in the developing neocortex.Competing Interest StatementThe authors have declared no competing interest.