TY - JOUR T1 - CancerMIRNome: an interactive analysis and visualization database for miRNome profiles of human cancer JF - bioRxiv DO - 10.1101/2020.10.04.325670 SP - 2020.10.04.325670 AU - Ruidong Li AU - Han Qu AU - Shibo Wang AU - John M. Chater AU - Xuesong Wang AU - Yanru Cui AU - Lei Yu AU - Rui Zhou AU - Qiong Jia AU - Ryan Traband AU - Meiyue Wang AU - Weibo Xie AU - Dongbo Yuan AU - Jianguo Zhu AU - Wei-De Zhong AU - Zhenyu Jia Y1 - 2021/01/01 UR - http://biorxiv.org/content/early/2021/08/01/2020.10.04.325670.abstract N2 - MicroRNAs (miRNAs), which play critical roles in gene regulatory networks, have emerged as promising diagnostic and prognostic biomarkers for human cancer. In particular, circulating miRNAs that are secreted into circulation exist in remarkably stable forms, and have enormous potential to be leveraged as non-invasive biomarkers for early cancer detection. Novel and user-friendly tools are desperately needed to facilitate data mining of the vast amount of miRNA expression data from The Cancer Genome Atlas (TCGA) and large-scale circulating miRNA profiling studies. To fill this void, we developed CancerMIRNome, a comprehensive database for the interactive analysis and visualization of miRNA expression profiles based on 10,998 samples from 33 TCGA projects and 21,993 samples from 40 public circulating miRNome datasets. A series of cutting-edge bioinformatics tools and machine learning algorithms have been packaged in CancerMIRNome, allowing for the pan-cancer analysis of a miRNA of interest across multiple cancer types and the comprehensive analysis of miRNome profiles to identify dysregulated miRNAs and develop diagnostic or prognostic signatures. The data analysis and visualization modules will greatly facilitate the exploit of the valuable resources and promote translational application of miRNA biomarkers in cancer. The CancerMIRNome database is publicly available at http://bioinfo.jialab-ucr.org/CancerMIRNome.Competing Interest StatementThe authors have declared no competing interest. ER -