RT Journal Article
SR Electronic
T1 Auditory cortex activation is modulated nonlinearly by stimulation duration: A functional near-infrared spectroscopy (fNIRS) study
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.08.02.454752
DO 10.1101/2021.08.02.454752
A1 Yi Fan Zhang
A1 Anne Lasfargue
A1 Isabelle Berry
YR 2021
UL http://biorxiv.org/content/early/2021/08/04/2021.08.02.454752.abstract
AB Functional near-infrared spectroscopy (NIRS) is an increasingly popular method in hearing research. However, few studies have considered efficient stimulation parameters for fNIRS auditory experimental design. The objectives of our study are (1) to characterize the auditory hemodynamic responses to trains of white noise with increasing stimulation durations (8s, 10s, 15s, 20s) in terms of amplitude and response linearity; (2) to identify the most-efficient stimulation duration using fNIRS; and (3) to generalize results to more ecological environmental stimuli. We found that cortical activity is augmented following the increments in stimulation durations and reaches a plateau after about 15s of stimulation. The linearity analysis showed that this augmentation due to stimulation duration is not linear in the auditory cortex, the non-linearity being more pronounced for longer durations (15s and 20s). The 15s block duration that we propose as optimal precludes signal saturation, is associated with a high response amplitude and a relatively short total experimental duration. Moreover, the 15s duration remains optimal independently of the nature of presented sounds. The sum of these findings suggests that 15s stimulation duration used in the appropriate experimental setup allows researchers to acquire optimal fNIRS signal quality.Competing Interest StatementThe authors have declared no competing interest.deoxy-HbdeoxyhemoglobinfNIRSfunctional near-infrared spectroscopyfMRIfunctional magnetic resonance imagingHbOOxygenated haemoglobinHbRDeoxygenated hemoglobinHbTTotal hemoglobin concentrationHDRhemodynamic responseLHLeft hemisphereoxy-HboxyhemoglobinRHRight hemisphereSNRsignal-to-noise ratio