PT  - JOURNAL ARTICLE
AU  - Olga Chervova
AU  - Lucia Conde
AU  - José Afonso Guerra-Assunção
AU  - Ismail Moghul
AU  - Amy P. Webster
AU  - Alison Berner
AU  - Elizabeth Larose Cadieux
AU  - Yuan Tian
AU  - Vitaly Voloshin
AU  - Rifat Hamoudi
AU  - Javier Herrero
AU  - Stephan Beck
TI  - The Personal Genome Project-UK: an open access resource of human multi-omics data
AID  - 10.1101/566711
DP  - 2019 Jan 01
TA  - bioRxiv
PG  - 566711
4099  - http://biorxiv.org/content/early/2019/03/04/566711.short
4100  - http://biorxiv.org/content/early/2019/03/04/566711.full
AB  - Integrative analysis of multi-omics data is a powerful approach for gaining functional insights into biological and medical processes. Conducting these multifaceted analyses on human samples is often complicated by the fact that the raw sequencing output is rarely available under open access. The Personal Genome Project UK (PGP-UK) is one of few resources that recruits its participants under open consent and makes the resulting multi-omics data freely and openly available. As part of this resource, we describe the PGP-UK multi-omics reference panel consisting of ten genomic, methylomic and transcriptomic data. Specifically, we outline the data processing, quality control and validation procedures which were implemented to ensure data integrity and exclude sample mix-ups. In addition, we provide a REST API to facilitate the download of the entire PGP-UK dataset. The data are also available from two cloud-based environments, providing platforms for free integrated analysis. In conclusion, the genotype-validated PGP-UK multi-omics human reference panel described here provides a valuable new open access resource for integrated analyses in support of personal and medical genomics.