PT  - JOURNAL ARTICLE
AU  - Teeraratkul, Chayut
AU  - Mukherjee, Debanjan
TI  - Microstructure Aware Modeling Of Biochemical Transport In Arterial Blood Clots
AID  - 10.1101/2021.01.25.428179
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.01.25.428179
4099  - http://biorxiv.org/content/early/2021/08/12/2021.01.25.428179.short
4100  - http://biorxiv.org/content/early/2021/08/12/2021.01.25.428179.full
AB  - Flow-mediated transport of biochemical species is central to thrombotic phenomena. Comprehensive three-dimensional modeling of flow-mediated transport around realistic macroscale thrombi poses challenges owing to their arbitrary heterogeneous microstructure. Here, we develop a microstructure aware model for species transport within and around a macroscale thrombus by devising a custom preconditioned fictitious domain formulation for thrombus-hemodynamics interactions, and coupling it with a fictitious domain advection-diffusion formulation for transport. Microstructural heterogeneities are accounted through a hybrid discrete particle-continuum approach for the thrombus interior. We present systematic numerical investigations on unsteady arterial flow within and around a three-dimensional macroscale thrombus; demonstrate the formation of coherent flow structures around the thrombus which organize advective transport; illustrate the role of the permeation processes at the thrombus boundary and subsequent intra-thrombus transport; and characterize species transport from bulk flow to the thrombus boundary and vice versa.Competing Interest StatementThe authors have declared no competing interest.