PT  - JOURNAL ARTICLE
AU  - Pascarella, Stefano
AU  - Ciccozzi, Massimo
AU  - Bianchi, Martina
AU  - Benvenuto, Domenico
AU  - Cauda, Roberto
AU  - Cassone, Antonio
TI  - Cutting epitopes to survive: the case of lambda variant
AID  - 10.1101/2021.08.14.456353
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.08.14.456353
4099  - http://biorxiv.org/content/early/2021/08/16/2021.08.14.456353.short
4100  - http://biorxiv.org/content/early/2021/08/16/2021.08.14.456353.full
AB  - This manuscript concisely reports an in-silico study on the potential impact of the Spike protein mutations on immuno-escape ability of SARS-CoV-2 lambda variant. Biophysical and bioinformatics data suggest that a combination of shortening immunogenic epitope loops and generation of potential N-glycosylation sites may be a viable adaptation strategy potentially allowing this emerging viral variant escaping host immunity.Competing Interest StatementThe authors have declared no competing interest.