RT Journal Article
SR Electronic
T1 Cutting epitopes to survive: the case of lambda variant
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.08.14.456353
DO 10.1101/2021.08.14.456353
A1 Pascarella, Stefano
A1 Ciccozzi, Massimo
A1 Bianchi, Martina
A1 Benvenuto, Domenico
A1 Cauda, Roberto
A1 Cassone, Antonio
YR 2021
UL http://biorxiv.org/content/early/2021/08/16/2021.08.14.456353.abstract
AB This manuscript concisely reports an in-silico study on the potential impact of the Spike protein mutations on immuno-escape ability of SARS-CoV-2 lambda variant. Biophysical and bioinformatics data suggest that a combination of shortening immunogenic epitope loops and generation of potential N-glycosylation sites may be a viable adaptation strategy potentially allowing this emerging viral variant escaping host immunity.Competing Interest StatementThe authors have declared no competing interest.