RT Journal Article
SR Electronic
T1 Oxidative stress, telomere length, and frailty in an old age population
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 414680
DO 10.1101/414680
A1 Martínez-Ezquerro José Darío
A1 Rodriguez-Castañeda Aleida
A1 Ortiz-Ramirez Mauricio
A1 Sanchez-Garcia Sergio
A1 Rosas-Vargas Haydee
A1 Sanchez-Arenas Rosalinda
A1 Garcia-delaTorre Paola
YR 2019
UL http://biorxiv.org/content/early/2019/03/04/414680.abstract
AB Background and objectives A global aging population requires focus on the risk factors for unhealthy aging, preventive medicine, and chronic disease management. The identification of adverse health outcomes in older adults has been addressed by the characterization of frailty as a biological syndrome. On the other hand, oxidative stress and telomere length have been suggested as biomarkers of aging. Here we evaluated the association of oxidative stress, telomere length, and frailty in an old age population.Research design and methods This was a cross-sectional study based on 2015 data from 202 members from the Cohort of Obesity, Sarcopenia and Frailty of Older Mexican Adults (n=202; gender F/M ratio: 133/69; mean age: 69.89 ± 7.39 years). Reactive oxygen species (ROS) were measured by dichlorofluorescin diacetate, and lipid peroxidation by malondialdehyde. Telomere length was determined using qPCR with SYBR Green Master Mix.Results We found no effect of oxidative stress on telomere length or frailty, but association between telomere length and frailty. Oxidative stress, measured only as ROS and lipid peroxidation, seems to reach a homeostatic level in our older population, which has no effect on telomere length or frailty status. On the other hand, telomere length is associated with frailty, an accurate identifier of health outcome.Discussion and implications Hence, it would seem that telomere length could eventually be used as a marker to discriminate between healthy and unhealthy aging, but oxidative stress is not suited as a biomarker but perhaps just as part of the progression of unhealthy aging.HighlightsOxidative stress has no effect on telomere length or frailty status in older adultsTelomere length is associated to frailty status in older adultsBiomarkers to help define frailty are needed for a better assessment of healthy ageing