RT Journal Article
SR Electronic
T1 The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.08.18.456894
DO 10.1101/2021.08.18.456894
A1 Jeeyun Chung
A1 Joongkyu Park
A1 Zon Weng Lai
A1 Talley J. Lambert
A1 Ruth C. Richards
A1 Robert V. Farese, Jr.
A1 Tobias C. Walther
YR 2021
UL http://biorxiv.org/content/early/2021/08/19/2021.08.18.456894.abstract
AB Lipid droplets (LDs) are crucial organelles for energy storage and lipid homeostasis. Autophagy of LDs is an important pathway for their catabolism, but the molecular mechanisms mediating targeting of LDs for degradation by selective autophagy (lipophagy) are unknown. Here we identify spartin as a receptor localizing to LDs and interacting with core autophagy machinery, and we show that spartin is required to deliver LDs to lysosomes for triglyceride (TG) mobilization. Mutations in SPART (encoding spartin) lead to Troyer syndrome, a form of hereditary spastic paraplegia. We find that interfering with spartin function leads to LD and TG accumulation in motor cortex neurons of mice. Our findings thus identify spartin as a lipophagy receptor and suggest that impaired LD turnover may contribute to Troyer syndrome development.Competing Interest StatementThe authors have declared no competing interest.