PT  - JOURNAL ARTICLE
AU  - Iman Sadeghi
AU  - Juan D. Gispert
AU  - Emilio Palumbo
AU  - Manuel Muñoz-Aguirre
AU  - Valentin Wucher
AU  - Valeria D’Argenio
AU  - Gabriel Santpere
AU  - Arcadi Navarro
AU  - Roderic Guigo
AU  - Natàlia Vilor-Tejedor
TI  - Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders
AID  - 10.1101/2021.08.16.456345
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.08.16.456345
4099  - http://biorxiv.org/content/early/2021/08/20/2021.08.16.456345.short
4100  - http://biorxiv.org/content/early/2021/08/20/2021.08.16.456345.full
AB  - Neurodegenerative and neuropsychiatric disorders (ND-NPs) are multifactorial, polygenic and complex behavioral phenotypes caused by brain abnormalities. Large-scale collaborative efforts have tried to identify the genetic architecture of these conditions. However, specific and shared underlying molecular pathobiology of brain illnesses is not clear. Here, we examine transcriptome-wide characterization of eight conditions, using a total of 2,633 post-mortem brain samples from patients with Alzheimer’s disease (AD), Parkinson’s disease (PD), Progressive Supranuclear Palsy (PSP), Pathological Aging (PA), Autism Spectrum Disorder (ASD), Schizophrenia (Scz), Major Depressive Disorder (MDD), and Bipolar Disorder (BP)–in comparison with 2,078 brain samples from matched control subjects.Similar transcriptome alterations were observed between NDs and NPs with the top correlations obtained between Scz-BP, ASD-PD, AD-PD, and Scz-ASD. Region-specific comparisons also revealed shared transcriptome alterations in frontal and temporal lobes across NPs and NDs. Co-expression network analysis identified coordinated dysregulations of cell-type-specific modules across NDs and NPs. This study provides a transcriptomic framework to understand the molecular alterations of NPs and NDs through their shared- and specific gene expression in the brain.Competing Interest StatementThe authors have declared no competing interest.