RT Journal Article
SR Electronic
T1 Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.08.16.456345
DO 10.1101/2021.08.16.456345
A1 Iman Sadeghi
A1 Juan D. Gispert
A1 Emilio Palumbo
A1 Manuel Muñoz-Aguirre
A1 Valentin Wucher
A1 Valeria D’Argenio
A1 Gabriel Santpere
A1 Arcadi Navarro
A1 Roderic Guigo
A1 Natàlia Vilor-Tejedor
YR 2021
UL http://biorxiv.org/content/early/2021/08/20/2021.08.16.456345.abstract
AB Neurodegenerative and neuropsychiatric disorders (ND-NPs) are multifactorial, polygenic and complex behavioral phenotypes caused by brain abnormalities. Large-scale collaborative efforts have tried to identify the genetic architecture of these conditions. However, specific and shared underlying molecular pathobiology of brain illnesses is not clear. Here, we examine transcriptome-wide characterization of eight conditions, using a total of 2,633 post-mortem brain samples from patients with Alzheimer’s disease (AD), Parkinson’s disease (PD), Progressive Supranuclear Palsy (PSP), Pathological Aging (PA), Autism Spectrum Disorder (ASD), Schizophrenia (Scz), Major Depressive Disorder (MDD), and Bipolar Disorder (BP)–in comparison with 2,078 brain samples from matched control subjects.Similar transcriptome alterations were observed between NDs and NPs with the top correlations obtained between Scz-BP, ASD-PD, AD-PD, and Scz-ASD. Region-specific comparisons also revealed shared transcriptome alterations in frontal and temporal lobes across NPs and NDs. Co-expression network analysis identified coordinated dysregulations of cell-type-specific modules across NDs and NPs. This study provides a transcriptomic framework to understand the molecular alterations of NPs and NDs through their shared- and specific gene expression in the brain.Competing Interest StatementThe authors have declared no competing interest.