PT  - JOURNAL ARTICLE
AU  - Bohdan B. Khomtchouk
AU  - Claes Wahlestedt
AU  - Wolfgang Nonner
TI  - A global perspective of codon usage
AID  - 10.1101/076679
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 076679
4099  - http://biorxiv.org/content/early/2016/09/21/076679.short
4100  - http://biorxiv.org/content/early/2016/09/21/076679.full
AB  - Diversity of codon usage across 2730 genomes from different taxa is analyzed with non-parametric methods. Usages range from near-uniform recruitment of different codons (limited by amino acid stoichiometry of encoded proteomes) to two distinct, non-uniform recruitments of nearly exclusive subsets of different codons. Intermediate usages are described as a variation from one distinct nonuniform usage to the other that involves joint, proportionate changes in the frequencies of most different codons. The two distinct non-uniform usages define two distinct genetic codes of which one employs A/U, and the other C/G, as third bases.