RT Journal Article
SR Electronic
T1 Testing for correlation between traits under directional evolution
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 566349
DO 10.1101/566349
A1 Manuela Royer-Carenzi
A1 Gilles Didier
YR 2019
UL http://biorxiv.org/content/early/2019/03/04/566349.abstract
AB Being confounding factors, directional trends are likely to make two quantitative traits appear as spuriously correlated. By determining the probability distributions of independent contrasts when traits evolve following Brownian motions with linear trends, we show that the standard independent contrasts can not be used to test for correlation in this situation. We propose a multiple regression approach which corrects the bias caused by directional evolution.Our approach is assessed and compared with three previous correlation tests on data simulated in various situations and overall outperforms all the other methods. The approach is next illustrated on a real dataset to test for correlation between hominin cranial capacity and body mass.