TY - JOUR T1 - Cell competition between wild-type and JAK2V617F mutant cells prevents disease relapse after stem cell transplantation in a murine model of myeloproliferative neoplasm JF - bioRxiv DO - 10.1101/2021.08.24.457589 SP - 2021.08.24.457589 AU - Haotian Zhang AU - Melissa Castiglione AU - Lei Zheng AU - Huichun Zhan Y1 - 2021/01/01 UR - http://biorxiv.org/content/early/2021/08/26/2021.08.24.457589.abstract N2 - Disease relapse after allogeneic stem cell transplantation is a major cause of treatment-related morbidity and mortality in patients with myeloproliferative neoplasms (MPNs). The cellular and molecular mechanisms for MPN relapse are not well understood. Here, we established a murine model of MPN relapse, in which ∼60% of the MPN recipient mice develop disease relapse after receiving stem cell transplantation with wild-type marrow donor. Using this model, we find that impaired wild-type cell function is associated with MPN disease relapse. We also show that competition between wild-type and JAK2V617F mutant cells can modulate the immune cell composition and PD-L1 expression induced by the JAK2V617F oncogene. These results suggest that cell competition between wild-type donor cells and JAK2V617F mutant recipient cells can prevent MPN disease relapse after stem cell transplantation.Competing Interest StatementThe authors have declared no competing interest. ER -