PT - JOURNAL ARTICLE AU - Benjamin C. Tendler AU - Taylor Hanayik AU - Olaf Ansorge AU - Sarah Bangerter-Christensen AU - Gregory S. Berns AU - Mads F. Bertelsen AU - Katherine L. Bryant AU - Sean Foxley AU - Martijn P. van den Heuvel AU - Amy F.D. Howard AU - Istvan Huszar AU - Alexandre A. Khrapitchev AU - Anna Leonte AU - Paul R. Manger AU - Ricarda A.L. Menke AU - Jeroen Mollink AU - Duncan Mortimer AU - Menuka Pallebage-Gamarallage AU - Lea Roumazeilles AU - Jerome Sallet AU - Lianne H. Scholtens AU - Connor Scott AU - Adele Smart AU - Martin R. Turner AU - Chaoyue Wang AU - Saad Jbabdi AU - Rogier B. Mars AU - Karla L. Miller TI - The Digital Brain Bank, an open access platform for post-mortem datasets AID - 10.1101/2021.06.21.449154 DP - 2021 Jan 01 TA - bioRxiv PG - 2021.06.21.449154 4099 - http://biorxiv.org/content/early/2021/09/01/2021.06.21.449154.short 4100 - http://biorxiv.org/content/early/2021/09/01/2021.06.21.449154.full AB - Post-mortem MRI provides the opportunity to acquire high-resolution datasets to investigate neuroanatomy, and validate the origins of image contrast through microscopy comparisons. We introduce the Digital Brain Bank (open.win.ox.ac.uk/DigitalBrainBank), an interactive data discovery and release platform providing open access to curated, multimodal post-mortem neuroimaging datasets. Datasets span three themes - Digital Neuroanatomist: datasets for detailed neuroanatomical investigations; Digital Brain Zoo: datasets for comparative neuroanatomy; Digital Pathologist: datasets for neuropathology investigations. The first Digital Brain Bank release includes twenty one distinctive whole-brain diffusion MRI datasets for structural connectivity investigations, alongside microscopy and complementary MRI modalities. This includes one of the highest-resolution whole-brain human diffusion MRI datasets ever acquired, whole-brain diffusion MRI in fourteen non-human primate species, and one of the largest post-mortem whole-brain cohort imaging studies in neurodegeneration. Taken together, the Digital Brain Bank provides a cross-scale, cross-species investigation framework facilitating the incorporation of post-mortem data into neuroimaging studies.Competing Interest StatementThe authors have declared no competing interest.