RT Journal Article
SR Electronic
T1 Whole-genome sequence analysis unveils different origins of European and Asiatic mouflon and domestication-related genes in sheep
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.09.07.458675
DO 10.1101/2021.09.07.458675
A1 Ze-Hui Chen
A1 Ya-Xi Xu
A1 Xing-Long Xie
A1 Dong-Feng Wang
A1 Diana Aguilar-Gómez
A1 Guang-Jian Liu
A1 Xin Li
A1 Ali Esmailizadeh
A1 Vahideh Rezaei
A1 Juha Kantanen
A1 Innokentyi Ammosov
A1 Maryam Nosrati
A1 Kathiravan Periasamy
A1 David W. Coltman
A1 Johannes A. Lenstra
A1 Rasmus Nielsen
A1 Meng-Hua Li
YR 2021
UL http://biorxiv.org/content/early/2021/09/09/2021.09.07.458675.abstract
AB The domestication and subsequent development of sheep are crucial events in the history of human civilization and the agricultural revolution. However, the impact of interspecific introgression on the genomic regions under domestication and subsequent selection remains unclear. Here, we analyze the whole genomes of domestic sheep and all their wild relative species. We found introgression from wild sheep such as the snow sheep and its American relatives (bighorn and thinhorn sheep) into urial, Asiatic and European mouflons. We observed independent events of adaptive introgression from wild sheep into the Asiatic and European mouflons, as well as shared introgressed regions from both snow sheep and argali into Asiatic mouflon before or during the domestication process. We revealed European mouflons arose through hybridization events between a now extinct sheep in Europe and feral domesticated sheep around 6,000 – 5,000 years BP. We also unveiled later introgressions from wild sheep to their sympatric domestic sheep after domestication. Several of the introgression events contain loci with candidate domestication genes (e.g., PAPPA2, NR6A1, SH3GL3, RFX3 and CAMK4), associated with morphological, immune, reproduction or production traits (wool/meat/milk). We also detected introgression events that introduced genes related to nervous response (NEURL1), neurogenesis (PRUNE2), hearing ability (USH2A) and placental viability (PAG11 and PAG3) to domestic sheep and their ancestral wild species from other wild species.Competing Interest StatementThe authors have declared no competing interest.