RT Journal Article
SR Electronic
T1 Visual Processing During the Interictal Period Between Migraines: A Meta-Analysis
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.09.13.459979
DO 10.1101/2021.09.13.459979
A1 Timucin Sezai
A1 Vinh Nguyen
A1 Nina Riddell
A1 Melanie J. Murphy
A1 Sheila G. Crewther
YR 2021
UL http://biorxiv.org/content/early/2021/09/15/2021.09.13.459979.abstract
AB Migraine is a poorly understood neurological disorder and a leading cause of disability in young adults. Migraines are characterized by severe pulsating unilateral headache and visual symptoms. Whether visual function is also impaired in the interictal period between migraines remains controversial. Thus, this meta-analysis investigated the evidence for altered visual function as measured electrophysiologically via pattern-reversal visual evoked potential (VEP) amplitudes and habituation in adult migraineurs with or without visual aura and control in the interictal period. Twenty-three studies were selected for random effects meta-analysis, demonstrating slightly diminished VEP amplitudes and substantially reduced habituation in the early P100 component in migraineurs without aura and with aura compared to controls. No differences were found between migraineurs with and without aura. Although heterogeneity between studies and insufficient published data for VEP latencies and the earlier N75 VEP component data was observed and require further testing, P100 anomalies may indicate abnormal functioning of the fast-conducting magnocellular visual pathway, in episodic migraineurs.Competing Interest StatementThe authors have declared no competing interest.