TY - JOUR T1 - MAGI-MS: Multiple seed-centric module discovery JF - bioRxiv DO - 10.1101/2021.09.14.460296 SP - 2021.09.14.460296 AU - Julie C. Chow AU - Ryan Zhou AU - Fereydoun Hormozdiari Y1 - 2021/01/01 UR - http://biorxiv.org/content/early/2021/09/16/2021.09.14.460296.abstract N2 - Complex disorders manifest by the interaction of multiple genetic and environmental factors. Through the construction of genetic modules that consist of highly co-expressed genes, it is possible to identify genes that participate in common biological pathways relevant to specific phenotypes. We have previously developed tools MAGI and MAGI-S for genetic module discovery by incorporating co-expression and protein-interaction networks. Here we introduce an extension to MAGI-S, denoted as Merging Affected Genes into Integrated Networks - Multiple Seeds (MAGI-MS), that permits the user to further specify a disease pathway of interest by selecting multiple seed genes likely to function in the same molecular mechanism. By providing MAGI-MS with pairs of seed genes involved in processes underlying certain classes of neurodevelopmental disorders, such as epilepsy, we demonstrate that MAGI-MS can reveal modules enriched in genes relevant to chemical synaptic transmission, glutamatergic synapse, and other functions associated with the provided seed genes.Availability and implementation MAGI-MS is free and is available at: https://github.com/jchow32/MAGI-MSCompeting Interest StatementThe authors have declared no competing interest. ER -