RT Journal Article SR Electronic T1 Principles governing the topological organization of object selectivities in ventral temporal cortex JF bioRxiv FD Cold Spring Harbor Laboratory SP 2021.09.15.460220 DO 10.1101/2021.09.15.460220 A1 Zhang, Yiyuan A1 Zhou, Ke A1 Bao, Pinglei A1 Liu, Jia YR 2021 UL http://biorxiv.org/content/early/2021/09/17/2021.09.15.460220.abstract AB To achieve the computational goal of rapidly recognizing miscellaneous objects in the environment despite large variations in their appearance, our mind represents objects in a high-dimensional object space to provide separable category information and enable the extraction of different kinds of information necessary for various levels of the visual processing. To implement this abstract and complex object space, the ventral temporal cortex (VTC) develops different object-selective regions with certain topological organization as the physical substrate. However, the principle that governs the topological organization of object selectivities in the VTC remains unclear. Here, equipped with the wiring cost minimization principle constrained by the wiring length of neurons in human temporal lobe, we constructed a hybrid self-organizing map (SOM) model as an artificial VTC (VTC-SOM) to explain how the abstract and complex object space is faithfully implemented in the brain. In two in silico experiments with the empirical brain imaging and single-unit data, our VTC-SOM predicted the topological structure of fine-scale functional regions (face-, object-, body-, and place-selective regions) and the boundary (i.e., middle Fusiform Sulcus) in large-scale abstract functional maps (animate vs. inanimate, real-word large-size vs. small-size, central vs. peripheral), with no significant loss in functionality (e.g., categorical selectivity, a hierarchy of view-invariant representations). These findings illustrated that the simple principle utilized in our model, rather than multiple hypotheses such as temporal associations, conceptual knowledge, and computational demands together, was apparently sufficient to determine the topological organization of object-selectivities in the VTC. In this way, the high-dimensional object space is implemented in a two-dimensional cortical surface of the brain faithfully.Competing Interest StatementThe authors have declared no competing interest.