TY - JOUR T1 - An enhanced inverted encoding model for neural reconstructions JF - bioRxiv DO - 10.1101/2021.05.22.445245 SP - 2021.05.22.445245 AU - Paul S. Scotti AU - Jiageng Chen AU - Julie D. Golomb Y1 - 2021/01/01 UR - http://biorxiv.org/content/early/2021/09/21/2021.05.22.445245.abstract N2 - Inverted encoding models (IEMs) have recently become a popular method for investigating neural representations by reconstructing the contents of perception, attention, and memory from neuroimaging data. However, the standard IEM procedure can produce spurious results and interpretation issues. Here we present a novel modification to IEMs (“enhanced inverted encoding modeling,” eIEM) that addresses key issues inherent in the standard IEM procedure, improves the flexibility and interpretability of stimulus reconstructions, and provides trial-by-trial stimulus predictions and goodness-of-fit estimates. Our modifications are advantageous due to our decoding metric taking into account the choice of population-level tuning functions and employing a prediction error-based metric directly comparable across experiments. Our modifications also allow trial-by-trial confidence estimates independent of prediction error which can be used to threshold reconstructions and improve neural decoding performance and brain-behavior correlations. We validate the improved utility of eIEM across three fMRI datasets and offer a Python package for easy implementation.Competing Interest StatementThe authors have declared no competing interest. ER -