PT  - JOURNAL ARTICLE
AU  - Julie Livingstone
AU  - Yu-Jia Shiah
AU  - Takafumi N. Yamaguchi
AU  - Lawrence E. Heisler
AU  - Vincent Huang
AU  - Robert Lesurf
AU  - Tsumugi Gebo
AU  - Benjamin Carlin
AU  - Stefan Eng
AU  - Erik Drysdale
AU  - Jeffrey Green
AU  - Theodorus van der Kwast
AU  - Robert G. Bristow
AU  - Michael Fraser
AU  - Paul C. Boutros
TI  - The Telomere Length Landscape of Prostate Cancer
AID  - 10.1101/2021.05.22.445239
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.05.22.445239
4099  - http://biorxiv.org/content/early/2021/09/22/2021.05.22.445239.short
4100  - http://biorxiv.org/content/early/2021/09/22/2021.05.22.445239.full
AB  - Replicative immortality is a hallmark of cancer, and can be achieved through telomere lengthening and maintenance. We report telomere lengths (TLs) of 392 localized prostate cancer tumours and characterize their relationship to genomic, transcriptomic and proteomic features. Shorter tumour TLs were associated with elevated genomic instability, including single-nucleotide variants, indels and structural variants. Genes involved in cell proliferation and signaling were correlated with tumour TL at all levels of the central dogma. TL was also associated with multiple clinical features of a tumour. Longer TLs in non-tumour samples were associated with a lower rate of biochemical relapse after definitive local therapy. Our analysis integrates multi-omics data to illuminate the relationship of specific genomic alterations in a tumour and TL in prostate cancer. Although the role of telomere length in cancer has been well studied, its association to genomic features is less well known. We describe the multi-level integration of telomere length, genomics, transcriptomics and proteomics in localized prostate cancer. Patient Summary We examined the association between telomere length and multiple omics-level data in prostate cancer. We observed that traditional telomere mutations are rare in prostate cancer and that telomere length is associated with multiple measure of genomic instability.Competing Interest StatementThe authors have declared no competing interest.