PT  - JOURNAL ARTICLE
AU  - Aurelia A. Mapps
AU  - Erica Boehm
AU  - Corrine Beier
AU  - William T. Keenan
AU  - Jennifer Langel
AU  - Michael Liu
AU  - Samer Hattar
AU  - Haiqing Zhao
AU  - Emmanouil Tampakakis
AU  - Rejji Kuruvilla
TI  - Satellite glia are essential modulators of sympathetic neuron survival, activity, and autonomic function
AID  - 10.1101/2021.09.23.461591
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.09.23.461591
4099  - http://biorxiv.org/content/early/2021/09/23/2021.09.23.461591.short
4100  - http://biorxiv.org/content/early/2021/09/23/2021.09.23.461591.full
AB  - Satellite glia are the major glial cells in sympathetic ganglia, enveloping neuronal cell bodies. Despite this intimate association, how satellite glia contribute to sympathetic functions remain unclear. Here, we show that satellite glia are critical for metabolism, survival, and activity of sympathetic neurons and modulate autonomic behaviors in mice. Adult ablation of satellite glia results in impaired mTOR signaling, soma atrophy, reduced noradrenergic enzymes, and loss of sympathetic neurons. However, persisting neurons have elevated activity, and satellite glia-ablated mice show increased pupil dilation and heart rate, indicative of enhanced sympathetic tone. Satellite glia-specific deletion of Kir4.1, an inward-rectifying potassium channel, largely recapitulates the cellular defects observed in glia-ablated mice, suggesting that satellite glia act in part via extracellular K+ buffering. These findings highlight neuron-satellite glia as functional units in regulating sympathetic output, with implications for disorders linked to sympathetic hyper-activity such as cardiovascular disease and hypertension.Competing Interest StatementThe authors have declared no competing interest.