PT  - JOURNAL ARTICLE
AU  - Kuijjer, Marieke L.
AU  - Glass, Kimberly
TI  - Reconstructing Sample-Specific Networks using LIONESS
AID  - 10.1101/2021.09.27.461954
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.09.27.461954
4099  - http://biorxiv.org/content/early/2021/09/28/2021.09.27.461954.short
4100  - http://biorxiv.org/content/early/2021/09/28/2021.09.27.461954.full
AB  - We recently developed LIONESS, a method to estimate sample-specific networks based on the output of an aggregate network reconstruction approach. In this manuscript, we describe how to apply LIONESS to different network reconstruction algorithms and data types. We highlight how decisions related to data preprocessing may affect the output networks, discuss expected outcomes, and give examples of how to analyze and compare single sample networks.Competing Interest StatementThe authors have declared no competing interest.