RT Journal Article
SR Electronic
T1 Reconstructing Sample-Specific Networks using LIONESS
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.09.27.461954
DO 10.1101/2021.09.27.461954
A1 Kuijjer, Marieke L.
A1 Glass, Kimberly
YR 2021
UL http://biorxiv.org/content/early/2021/09/28/2021.09.27.461954.abstract
AB We recently developed LIONESS, a method to estimate sample-specific networks based on the output of an aggregate network reconstruction approach. In this manuscript, we describe how to apply LIONESS to different network reconstruction algorithms and data types. We highlight how decisions related to data preprocessing may affect the output networks, discuss expected outcomes, and give examples of how to analyze and compare single sample networks.Competing Interest StatementThe authors have declared no competing interest.