RT Journal Article
SR Electronic
T1 Naming Human Diseases: Ethical Principles of Curating Exclusive Substitute for Inopportune Nosology
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.05.01.442270
DO 10.1101/2021.05.01.442270
A1 Zhiwen Hu
A1 Ya Chen
A1 Yuling Song
A1 Zhongliang Yang
A1 Hui Huang
YR 2021
UL http://biorxiv.org/content/early/2021/10/02/2021.05.01.442270.abstract
AB Background In the medical sphere, understanding naming conventions strengthen the integrity of naming human diseases remains nominal rather than substantial yet. Since the current nosology-based standard for human diseases could not offer a one-size-fits-all corrective mechanism, many idiomatic but flawed names frequently appear in scientific literature and news outlets at the cost of sociocultural impacts.Objective We attempt to examine the ethical oversights of current naming practices and propose heuristic rationales and approaches to determine a pithy name instead of an inopportune nosology.Methods First, we examined the compiled global online news volumes and emotional tones on some inopportune nosology like German measles, Middle Eastern Respiratory Syndrome, Spanish flu, Hong Kong flu, and Huntington’s disease in the wake of COVID-19. Second, we prototypically scrutinize the lexical dynamics and pathological differentials of German measles and common synonyms by leveraging the capacity of the Google Books Ngram Corpus. Third, we demonstrated the empirical approaches to curate an exclusive substitute for an anachronistic nosology German measles based on deep learning models and post-hoc explanations.Results The infodemiological study shows that the public informed the offensive names with extremely negative tones in textual and visual narratives. The findings of the historiographical study indicate that many synonyms of German measles did not survive, while German measles became an anachronistic usage, and rubella has taken the dominant place since 1994. The PubMedBERT model could identify rubella as a potential substitution for German measles with the highest semantic similarity. The results of the semantic drift experiments further indicate that rubella tends to survive during the ebb and flow of semantic drift.Conclusions Our findings indicate that the nosological evolution of anachronistic names could result in sociocultural impacts without a corrective mechanism. To mitigate such impacts, we introduce some ethical principles for formulating an improved naming scheme. Based on deep learning models and post-hoc explanations, our illustrated experiments could provide hallmark references to the remedial mechanism of naming practices and pertinent credit allocations.Competing Interest StatementThe authors have declared no competing interest.BERTBidirectional Encoder Representations from TransformersCOVID-19Coronavirus Disease 2019GBNCGoogle Books Ngram CorpusGDELTGlobal Data on Events, Location and ToneICDInternational Classification of DiseasesICD-11Eleventh revision of the International Classification of DiseasesMERSMiddle Eastern Respiratory SyndromeOED OnlineOxford English Dictionary OnlinePCAPrincipal Component AnalysisPPMIPositive Pointwise Mutual InformationSARSSevere Acute Respiratory SyndromeSVDSingular Value DecompositionWHAWorld Health AssemblyWHOWorld Health Organization