RT Journal Article
SR Electronic
T1 Video-evoked fMRI BOLD responses are highly consistent across different data acquisition sites
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.10.04.463088
DO 10.1101/2021.10.04.463088
A1 Lisa Byrge
A1 Dorit Kliemann
A1 Ye He
A1 Hu Cheng
A1 J. Michael Tyszka
A1 Ralph Adolphs
A1 Daniel P. Kennedy
YR 2021
UL http://biorxiv.org/content/early/2021/10/05/2021.10.04.463088.abstract
AB Naturalistic imaging paradigms, in which participants view complex videos in the scanner, are increasingly used in human cognitive neuroscience. Videos evoke temporally synchronized brain responses that are similar across subjects as well as within subjects, but the reproducibility of these brain responses across different data acquisition sites has not yet been quantified. Here we characterize the consistency of brain responses across independent samples of participants viewing the same videos in fMRI scanners at different sites (Indiana University and Caltech). We compared brain responses collected at these different sites for two carefully matched datasets with identical scanner models, acquisition, and preprocessing details, along with a third unmatched dataset in which these details varied. Our overall conclusion is that for matched and unmatched datasets alike, video-evoked brain responses have high consistency across these different sites, both when compared across groups and across pairs of individuals. As one might expect, differences between sites were larger for unmatched datasets than matched datasets. Residual differences between datasets could in part reflect participant-level variability rather than scanner- or data-related effects. Altogether our results indicate promise for the development and, critically, generalization of video fMRI studies of individual differences in healthy and clinical populations alike.Competing Interest StatementThe authors have declared no competing interest.