PT  - JOURNAL ARTICLE
AU  - Mustafa S. Pir
AU  - Halil I. Bilgin
AU  - Ahmet Sayici
AU  - Fatih Coşkun
AU  - Furkan M. Torun
AU  - Pei Zhao
AU  - Yahong Kang
AU  - Sebiha Cevik
AU  - Oktay I. Kaplan
TI  - ConVarT: a search engine for matching human genetic variants with variants from non-human species
AID  - 10.1101/2021.01.07.424951
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.01.07.424951
4099  - http://biorxiv.org/content/early/2021/10/11/2021.01.07.424951.short
4100  - http://biorxiv.org/content/early/2021/10/11/2021.01.07.424951.full
AB  - The availability of genetic variants, together with phenotypic annotations from model organisms, facilitates comparing these variants with equivalent variants in humans. However, existing databases and search tools do not make it easy to scan for equivalent variants, namely “matching variants” (MatchVars) between humans and other organisms. Therefore, we developed an integrated search engine called ConVarT (http://www.convart.org/) for matching variants between humans, mice, and C. elegans. ConVarT incorporates annotations (including phenotypic and pathogenic) into variants, and these previously unexploited phenotypic MatchVars from mice and C. elegans can give clues about the functional consequence of human genetic variants. Our analysis shows that many phenotypic variants in different genes from mice and C. elegans, so far, have no counterparts in humans, and thus, can be useful resources when evaluating a relationship between a new human mutation and a disease.Competing Interest StatementThe authors have declared no competing interest.