RT Journal Article SR Electronic T1 ConVarT: a search engine for matching human genetic variants with variants from non-human species JF bioRxiv FD Cold Spring Harbor Laboratory SP 2021.01.07.424951 DO 10.1101/2021.01.07.424951 A1 Mustafa S. Pir A1 Halil I. Bilgin A1 Ahmet Sayici A1 Fatih Coşkun A1 Furkan M. Torun A1 Pei Zhao A1 Yahong Kang A1 Sebiha Cevik A1 Oktay I. Kaplan YR 2021 UL http://biorxiv.org/content/early/2021/10/11/2021.01.07.424951.abstract AB The availability of genetic variants, together with phenotypic annotations from model organisms, facilitates comparing these variants with equivalent variants in humans. However, existing databases and search tools do not make it easy to scan for equivalent variants, namely “matching variants” (MatchVars) between humans and other organisms. Therefore, we developed an integrated search engine called ConVarT (http://www.convart.org/) for matching variants between humans, mice, and C. elegans. ConVarT incorporates annotations (including phenotypic and pathogenic) into variants, and these previously unexploited phenotypic MatchVars from mice and C. elegans can give clues about the functional consequence of human genetic variants. Our analysis shows that many phenotypic variants in different genes from mice and C. elegans, so far, have no counterparts in humans, and thus, can be useful resources when evaluating a relationship between a new human mutation and a disease.Competing Interest StatementThe authors have declared no competing interest.