TY - JOUR T1 - ConVarT: a search engine for matching human genetic variants with variants from non-human species JF - bioRxiv DO - 10.1101/2021.01.07.424951 SP - 2021.01.07.424951 AU - Mustafa S. Pir AU - Halil I. Bilgin AU - Ahmet Sayici AU - Fatih Coşkun AU - Furkan M. Torun AU - Pei Zhao AU - Yahong Kang AU - Sebiha Cevik AU - Oktay I. Kaplan Y1 - 2021/01/01 UR - http://biorxiv.org/content/early/2021/10/11/2021.01.07.424951.abstract N2 - The availability of genetic variants, together with phenotypic annotations from model organisms, facilitates comparing these variants with equivalent variants in humans. However, existing databases and search tools do not make it easy to scan for equivalent variants, namely “matching variants” (MatchVars) between humans and other organisms. Therefore, we developed an integrated search engine called ConVarT (http://www.convart.org/) for matching variants between humans, mice, and C. elegans. ConVarT incorporates annotations (including phenotypic and pathogenic) into variants, and these previously unexploited phenotypic MatchVars from mice and C. elegans can give clues about the functional consequence of human genetic variants. Our analysis shows that many phenotypic variants in different genes from mice and C. elegans, so far, have no counterparts in humans, and thus, can be useful resources when evaluating a relationship between a new human mutation and a disease.Competing Interest StatementThe authors have declared no competing interest. ER -