RT Journal Article
SR Electronic
T1 Control of Parallel Hippocampal Output Pathways by Amygdalar Long-Range Inhibition
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.03.08.434367
DO 10.1101/2021.03.08.434367
A1 Rawan AlSubaie
A1 Ryan W S Wee
A1 Anne Ritoux
A1 Karyna Mishchanchuk
A1 Jessica Passlack
A1 Daniel Regester
A1 Andrew F MacAskill
YR 2021
UL http://biorxiv.org/content/early/2021/10/15/2021.03.08.434367.abstract
AB Projections from the basal amygdala (BA) to the ventral hippocampus (vH) are proposed to provide information about the rewarding or threatening nature of learned associations to support appropriate goal-directed and anxiety-like behaviour. Such behaviour occurs via the differential activity of multiple, parallel populations of pyramidal neurons in vH that project to distinct downstream targets, but the nature of BA input and how it connects with these populations is unclear. Using channelrhodopsin-2-assisted circuit mapping in mice, we show that BA input to vH consists of both excitatory and inhibitory projections. Excitatory input specifically targets BA- and nucleus accumbens-projecting vH neurons, and avoids prefrontal cortex-projecting vH neurons; while inhibitory input preferentially targets BA-projecting neurons. Through this specific connectivity, BA inhibitory projections gate place-value associations by controlling the activity of nucleus accumbens-projecting vH neurons. Our results define a parallel excitatory and inhibitory projection from BA to vH that can support goal-directed behaviour.Competing Interest StatementThe authors have declared no competing interest.