@article {Woo2021.10.13.464327, author = {Jae Hyung Woo and Habiba Azab and Andrew Jahn and Benjamin Hayden and Joshua W. Brown}, title = {The PRO model accounts for the anterior cingulate cortex role in risky decision-making and monitoring}, elocation-id = {2021.10.13.464327}, year = {2021}, doi = {10.1101/2021.10.13.464327}, publisher = {Cold Spring Harbor Laboratory}, abstract = {The anterior cingulate cortex (ACC) has been implicated in a number of functions including performance monitoring and decision making involving effort. The prediction of responses and outcomes (PRO) model has provided a unified account of much human and monkey ACC data involving anatomy, neurophysiology, EEG, fMRI, and behavior. Here we explore the computational nature of ACC with the PRO model, extending it to account specifically for both human and macaque monkey decision-making under risk, including both behavioral and neural data. We show that the PRO model can account for a number of additional effects related to outcome prediction, decision-making under risk, gambling behavior, and we show that the ACC represents the variance of uncertain outcomes, suggesting a link between ACC function and mean-variance theories of decision making. The PRO model provides a unified account of a large set of data regarding the ACC.Competing Interest StatementThe authors have declared no competing interest.}, URL = {https://www.biorxiv.org/content/early/2021/10/15/2021.10.13.464327}, eprint = {https://www.biorxiv.org/content/early/2021/10/15/2021.10.13.464327.full.pdf}, journal = {bioRxiv} }