TY - JOUR T1 - Genomic insights into the population history and biological adaptation of Southwestern Chinese Hmong-Mien people JF - bioRxiv DO - 10.1101/2021.10.16.463767 SP - 2021.10.16.463767 AU - Yan Liu AU - Jie Xie AU - Mengge Wang AU - Changhui Liu AU - Jingrong Zhu AU - Xing Zou AU - Wenshan Li AU - Lin Wang AU - Cuo Leng AU - Quyi Xu AU - Hui-Yuan Yeh AU - Chuan-Chao Wang AU - Xiaohong Wen AU - Chao Liu AU - Guanglin He Y1 - 2021/01/01 UR - http://biorxiv.org/content/early/2021/10/16/2021.10.16.463767.abstract N2 - Hmong-Mien-speaking (HM) populations, widely distributed in South China, North of Thailand, Laos and Vietnam, have experienced different settlement environments, dietary habits and pathogen exposure. However, their specific biological adaptation also remained largely uncharacterized, which is important in the population evolutionary genetics and Trans-Omics for regional Precision Medicine. Besides, the origin and genetic diversity of HM people and their phylogenetic relationship with surrounding modern and ancient populations are unknown. Here, we reported genome-wide SNPs in 52 representative Miao people and combined them with 144 HM people from 13 geographically representative populations to characterize the full genetic admixture and adaptive landscape of HM speakers. We found that obvious genetic substructures existed in geographically different HM populations and also identified one new ancestral lineage specifically exited in HM people, which spatially distributed from Sichuan and Guizhou in the North to Thailand in the South and temporally dated to at least 500 years. The sharing patterns of the newly-identified homogeneous ancestry component combined the estimated admixture times via the decay of Linkage Disequilibrium and haplotype sharing in GLOBETROTTER suggested that the modern HM-speaking populations originated from Southwest China and migrated southward recently, which is consistent with the reconstructed phenomena of linguistic and archeological documents. Additionally, we identified specific adaptive signatures associated with several important human nervous system biological functions. Our pilot work emphasized the importance of anthropologically-informed sampling and deeply genetic structure reconstruction via whole-genome sequencing in the next step in the deep Chinese population genomic diversity project (CPGDP), especially in the ethnolinguistic regions.Competing Interest StatementThe authors have declared no competing interest. ER -