PT  - JOURNAL ARTICLE
AU  - Chen Xie
AU  - Peiyuan Kang
AU  - Johan Cazals
AU  - Omar Morales Castelán
AU  - Jaona Randrianalisoa
AU  - Zhenpeng Qin
TI  - Single Pulse Heating of Nanoparticle Array for Biological Applications
AID  - 10.1101/2021.10.21.465356
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.10.21.465356
4099  - http://biorxiv.org/content/early/2021/10/23/2021.10.21.465356.short
4100  - http://biorxiv.org/content/early/2021/10/23/2021.10.21.465356.full
AB  - With the ability to convert external excitation into heat, nanomaterials play an essential role in many biomedical applications. Two modes of nanoparticle (NP) array heating, nanoscale-confined heating (NCH) and macroscale-collective heating (MCH), have been found and extensively studied. Despite this, the resulting biological response at protein level remains elusive. In this study, we developed a computational model to systematically investigate the single-pulsed heating of NP array and corresponding protein denaturation/activation. We found that NCH may lead to targeted protein denaturation, however, nanoparticle heating does not lead to nanoscale selective TRPV1 channel activation. The excitation duration and NP concentration are primary factors that determine a window for targeted protein denaturation, and together with heating power, we defined quantified boundaries for targeted protein denaturation. Our results boost our understandings in the NCH and MCH under realistic physical constraints and provide a robust guidance to customize biomedical platforms with desired NP heating.Competing Interest StatementThe authors have declared no competing interest.NPnanoparticle;TRPV1transient receptor potential cation channel subfamily V member 1;NCHnanoscale-selective heating;MCHmacroscale-collective heating;SLMspatial light modulation;ROSreactive oxygen species.