RT Journal Article
SR Electronic
T1 Bimodal Remapping of Visual Grids
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.10.30.466568
DO 10.1101/2021.10.30.466568
A1 Xiaoyang Long
A1 Jing Cai
A1 Bin Deng
A1 Zhe Sage Chen
A1 Sheng-Jia Zhang
YR 2021
UL http://biorxiv.org/content/early/2021/11/02/2021.10.30.466568.abstract
AB Spatially modulated neurons from the rat secondary visual cortex (V2) show grid-like firing patterns during freely foraging in open-field enclosures. However, the remapping of the V2 grid cells is not well understood. Here we report two classes of V2 grid cell populations with distinct remapping properties: one regular class with invariant grid field patterns, and the other bimodal class that has remapping induced by environmental manipulations such as changes in enclosure shape, size, orientation and lighting in a familiar environment. The bimodal V2 grid cell pattern remains stable regardless of the follow-up manipulations, but restores to the original firing pattern upon animal’s re-entry into the familiar environment on the next day or from the novel environment. The bimodal V2 grid cells are modulated with theta frequency during the course of remapping and stabilize quickly. We also found conjunctive bistable V2 grid cells with invariant head directional tuning. Overall, our results suggest a new grid cell mechanism in V2 that is different from the medial entorhinal cortex (MEC) grid cells.HighlightsBistable V2 grid cells display bimodal or bistable remappingV2 grid cell firing patterns are not disrupted in darknessV2 grid cells preserve theta frequency modulation during remappingCompeting Interest StatementThe authors have declared no competing interest.