RT Journal Article
SR Electronic
T1 Vitamin A and vitamin E metabolites comodulate amyloid-β aggregation
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.10.30.466561
DO 10.1101/2021.10.30.466561
A1 Priyanka Joshi
A1 Sean Chia
A1 Xiaoting Yang
A1 Michele Perni
A1 Johnny Habchi
A1 Michele Vendruscolo
YR 2021
UL http://biorxiv.org/content/early/2021/11/02/2021.10.30.466561.abstract
AB Alzheimer’s disease is characterized by the presence in the brain of amyloid plaques formed by the aberrant deposition of the amyloid-β peptide (Aβ). Since many vitamins are dysregulated in this disease, we explored whether these molecules participate in protein homeostasis by modulating Aβ aggregation. By screening 18 fat-soluble and water-soluble vitamins, we found that retinoic acid and α-tocopherol, two metabolites of vitamin A and vitamin E, respectively, affect Aβ aggregation both in vitro and in a C. elegans model of Alzheimer’s disease. We also show that effects of these two vitamin metabolites in combination can cancel each other out, suggesting that the complex composition of the cellular environment could have a protective role against protein aggregation through the simultaneous presence of aggregation promoters and inhibitors. Taken together, these results indicate that vitamins and their metabolites may be added to the list of components of the quality control system that regulate protein aggregation.Competing Interest StatementThe authors have declared no competing interest.