TY - JOUR T1 - The Genomic Prehistory of the Indigenous People of Uruguay JF - bioRxiv DO - 10.1101/2021.11.11.468260 SP - 2021.11.11.468260 AU - John Lindo AU - Rosseirys De La Rosa AU - Andre Luiz Campelo dos Santos AU - Mónica Sans AU - Michael DeGiorgio AU - Gonzalo Figueiro Y1 - 2021/01/01 UR - http://biorxiv.org/content/early/2021/11/16/2021.11.11.468260.abstract N2 - The prehistory of the people of Uruguay is greatly complicated by the dramatic and severe effects of European contact, as with most of the Americas. After the series of military campaigns that exterminated the last remnants of nomadic peoples, Uruguayan official history masked and diluted the former indigenous ethnic diversity into the narrative of a singular people that all but died out. Here we present the first whole genome sequences of the Indigenous people of the region before the arrival of Europeans, from an archaeological site in eastern Uruguay that dates from 2,000 years before present. We find a surprising connection to ancient individuals from Panama and eastern Brazil, but not to modern Amazonians. This result may be indicative of a distinct migration route into South America that may have occurred along the Atlantic coast. We also find a distinct ancestry previously undetected in South America. Though this work begins to piece together some of the demographic nuance of the region, the sequencing of ancient individuals from across Uruguay is needed to better understand the ancient prehistory and genetic diversity that existed before European contact, thereby helping to rebuild the history of the indigenous population of what is now Uruguay.Competing Interest StatementThe authors have declared no competing interest. ER -