RT Journal Article
SR Electronic
T1 Genetic polymorphisms in <em>COMT</em> and <em>BDNF</em> influence synchronization dynamics of human neuronal oscillations
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.11.16.468778
DO 10.1101/2021.11.16.468778
A1 Simola, Jaana
A1 Siebenhühner, Felix
A1 Myrov, Vladislav
A1 Kantojärvi, Katri
A1 Paunio, Tiina
A1 Palva, J. Matias
A1 Brattico, Elvira
A1 Palva, Satu
YR 2021
UL http://biorxiv.org/content/early/2021/11/19/2021.11.16.468778.abstract
AB Neuronal oscillations, their inter-areal synchronization and scale-free dynamics constitute fundamental mechanisms for cognition by regulating communication in neuronal networks. These oscillatory dynamics have large inter-individual variability that is partly heritable. However, the genetic underpinnings of oscillatory dynamics have remained poorly understood. We recorded resting-state magnetoencephalography (MEG) from 82 participants and investigated whether oscillation dynamics were influenced by genetic polymorphisms in Catechol-O-methyltransferase (COMT) Val158Met and brain-derived neurotrophic factor (BDNF) Val66Met. Both COMT and BDNF polymorphisms influenced local oscillation amplitudes and their long-range temporal correlations (LRTCs), while only BDNF polymorphism affected the strength of large-scale synchronization. Brain criticality framework and computational modelling of near-critical synchronization dynamics suggested that COMT and BDNF polymorphisms influenced local oscillations via differences in net excitation-inhibition balance. Our findings demonstrate that COMT and BDNF genetic polymorphisms contribute to inter-individual variability in local and large-scale synchronization dynamics of neuronal oscillations.Competing Interest StatementThe authors have declared no competing interest.5-HT5-hydroxytryptamineDAdopamineDANDorsal attention networkDMNDefault Mode networkFPNFrontoparietal networkLimLimbic systemNEnoradrenalineSMSomatomotor networkVANVentral attention networkVisVisual network