RT Journal Article
SR Electronic
T1 Suppressed prefrontal neuronal firing variability and impaired social representation in IRSp53-mutant mice
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.11.17.468945
DO 10.1101/2021.11.17.468945
A1 Woohyun Kim
A1 Young Woo Noh
A1 Seungjoon Lee
A1 Woochul Choi
A1 Se-Bum Paik
A1 Min Whan Jung
A1 Eunee Lee
A1 Eunjoon Kim
YR 2021
UL http://biorxiv.org/content/early/2021/11/19/2021.11.17.468945.abstract
AB Social deficit is a major feature of neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, and attention-deficit/hyperactivity disorder, but its neural mechanisms remain unclear. Here, we examined neuronal discharge characteristics in the medial prefrontal cortex (mPFC) of IRSp53-mutant mice, which show social deficits, during social approach. IRSp53-mutant excitatory mPFC neurons displayed an increase in baseline neuronal firing and decreases in variability and dynamic range of firing rates and burst firing during social and non-social target approaches compared to wild-type controls. As a consequence, their firing activity was less differential between social and non-social targets. In addition, there was a decrease in the proportion of excitatory mPFC neurons encoding social information but not that of those encoding non-social information. These results suggest that insufficient neuronal activity dynamics may underlie impaired cortical encoding of social information and social behaviors in IRSp53-mutant mice.Competing Interest StatementThe authors have declared no competing interest.