RT Journal Article
SR Electronic
T1 Context-Dependent Relationships between Locus Coeruleus Firing Patterns and Coordinated Neural Activity in the Anterior Cingulate Cortex
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.09.26.314831
DO 10.1101/2020.09.26.314831
A1 Siddhartha Joshi
A1 Joshua I. Gold
YR 2021
UL http://biorxiv.org/content/early/2021/11/22/2020.09.26.314831.abstract
AB Ascending neuromodulatory projections from the locus coeruleus (LC) affect cortical neural networks via the release of norepinephrine (NE). However, the exact nature of these neuromodulatory effects on neural activity patterns in vivo is not well understood. Here we show that in awake monkeys, LC activation is associated with changes in coordinated activity patterns in the anterior cingulate cortex (ACC). These relationships, which are largely independent of changes in firing rates of individual ACC neurons, depend on the type of LC activation: ACC pairwise correlations tend to be reduced when ongoing (baseline) LC activity increases but enhanced when external events evoke transient LC responses. Both relationships covary with pupil changes that reflect LC activation and arousal. These results suggest that modulations of information processing that reflect changes in coordinated activity patterns in cortical networks can result partly from ongoing, context-dependent, arousal-related changes in activation of the LC-NE system.Competing Interest StatementThe authors have declared no competing interest.