TY - JOUR T1 - The impact of Fisher’s Reproductive Compensation on raising equilibrium frequencies of semi-dominant, non-lethal mutations under mutation/selection balance JF - bioRxiv DO - 10.1101/2021.11.19.469230 SP - 2021.11.19.469230 AU - Ian M. Hastings Y1 - 2021/01/01 UR - http://biorxiv.org/content/early/2021/11/23/2021.11.19.469230.abstract N2 - Fisher’s reproductive compensation (fRC) occurs when a species’ demography means the death of an individual allows increased survival of his/her relatives, usually assumed to be full sibs. This likely occurs in many species, including humans. Several important recessive human genetic diseases cause early foetal/infant death allowing fRC to act on these mutations. The impact of fRC on these genetic conditions has been calculated and shown to be substantial as quantified by ω, the fold increase in equilibrium frequencies of the mutation under fRC compared to its absence i.e. ω=1.22 and ω=1.33 for autosomal and sex-linked loci, respectively. However, the impact of fRC on the frequency of the much large class of semi-dominant, non-lethal mutations is unknown. This is calculated here by a mixture of simulation and algebra and shown that ω=2-h*s and ω≈2-0.19s-0.85h*s for autosomal and sex-linked loci respectively where h is dominance (varied between 0.05 and 0.95) and s is selection coefficient (varied between 0.05 and 0.9). These results show that the actions of fRC can almost double equilibrium frequency of mutations with low values of h and/or s. The dynamics of fRC acting on this type of mutation are also identified and discussed.Competing Interest StatementThe authors have declared no competing interest. ER -