PT  - JOURNAL ARTICLE
AU  - Julia Y Kam
AU  - Tina Cheng
AU  - Danielle C Garland
AU  - Warwick J Britton
AU  - David M Tobin
AU  - Stefan H Oehlers
TI  - Inhibition of infection-induced vascular permeability modulates host leukocyte recruitment to <em>Mycobacterium marinum</em> granulomas in zebrafish
AID  - 10.1101/2021.11.23.469781
DP  - 2021 Jan 01
TA  - bioRxiv
PG  - 2021.11.23.469781
4099  - http://biorxiv.org/content/early/2021/11/23/2021.11.23.469781.short
4100  - http://biorxiv.org/content/early/2021/11/23/2021.11.23.469781.full
AB  - Mycobacterial granuloma formation involves significant stromal remodeling and the growth of leaky, granuloma-associated vasculature. These permeable blood vessels aid mycobacterial growth, as anti-angiogenic or vascular normalizing therapies are beneficial host-directed therapies in pre-clinical models of tuberculosis. Here we demonstrate that vascular normalization through vascular endothelial-protein tyrosine phosphatase inhibition decreases granuloma hypoxia, the opposite effect of hypoxia-inducing anti-angiogenic therapy. Vascular normalization leads to increased T cell and decreased neutrophil recruitment to granulomas, correlates of a protective immune response against mycobacterial infection.Competing Interest StatementThe authors have declared no competing interest.