RT Journal Article
SR Electronic
T1 F<sub>1</sub>F<sub>0</sub> ATP Hydrolysis is a Determinant of Metabolic Rate, a Correlate of Lifespan, and a Weakness of Cancer
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2021.10.28.466310
DO 10.1101/2021.10.28.466310
A1 Forrest, Michael David
YR 2021
UL http://biorxiv.org/content/early/2021/11/24/2021.10.28.466310.abstract
AB Dramatic rectal temperature decrease, in mice administered with a drug that specifically inhibits F1F0 ATP hydrolysis, suggests that F1F0 ATP hydrolysis is a major determinant of metabolic rate in vivo. Across twelve investigated species, less F1F0 ATP hydrolysis correlates with greater maximal lifespan. Specific drug inhibition of F1F0 ATP hydrolysis exerts potent anti-cancer activity in vitro.Competing Interest StatementThe author has filed for related patents.